Extreme events reveal our knowledge gaps about the consequences of disasters and their mitigation. Such gaps were posed by the surprise large-scale terror attack launched by Hamas on Israel on October 7th, 2023. Hamas ruthlessly targeted the 3,500 attendees of the Nova music festival, subjecting them to intense, life-threatening trauma over an extended duration. The attack took place shortly after sunrise, around the peak of the party, while many attendees were under the influence of mind-altering substances like MDMA, LSD, Ketamine, Psilocybin, and Cannabis, plausibly impacting their subjective experience and trauma processing. This unprecedented disaster poses significant challenges for clinicians in providing evidence-based therapy to a population that endured an experience that had never been studied before. Immediately following the event, Prof. Salomon, co-founded the NGO SafeHeart, to assist survivors of the music festival. Over 2,700 survivors have registered, providing a unique opportunity to study trauma processing under psychedelics. Together with Prof. Roee Admon, we have initiated a large-scale interdisciplinary study using behavioral, cognitive, emotional, physiological, and neural measurements to understand the mechanisms of trauma experienced under psychoactive substances and determine effective therapies for the affected community.